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Its beneficial effects are therefore retained in the body for a longer period of time

Although most of these data were generated in regenerative settings rather than during steady-state aging, they support a model in which aging can reduce the MuSC pool through probabilistic loss or dysfunction of MuSCs (or labeled lineages) without implying deterministic, subset-specific collapse of heterogeneity (Fig

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In the nervous system, inhibition of mTOR pathway, including its downstream effectors p70S6K and 4E-BP1, usually promotes neuronal apoptosis 11