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Both accumulated succinate and fumarate are potent inhibitors of prolyl 4-hydroxylases (PHDs)

Phosphorylated -catenin translocates to the nucleus, binds to TCF/LEF transcription factors, and promotes the expression of many target genes, including those involved in cell proliferation, anti-apoptosis, invasion, and angiogenesis (Fig

The peptide also enhances the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), critical molecules for neuronal survival and plasticity

They can imply sports-performance or rehabilitation benefit