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Inflammatory cells accumulate in the synovium, leading to the formation of a pannus that can destroy cartilage and further propagate the inflammatory process, eventually leading to clinical arthritis ( The symptoms of RA are associated with inflammation

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High choline intake in early life has been shown to improve outcomes in a mouse model of Alzheimers disease, regulating hyperexcitability, preserving hilar neurons, and enhancing spatial memory (164)

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