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Abstract Acetaminophen (APAP) is widely used as an over-the-counter fever reducer and pain reliever

It participates in Phase II detoxification pathways, where it conjugates with toxins, making them water-soluble and easier to excrete

The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

Individual results vary, and these medications are not appropriate for everyone

[1] [4] Phase 2 trials are designed to assess safety and preliminary efficacy in relatively controlled conditions