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In an early phase 1 study of healthy obese participants, setmelanotide demonstrated significant weight loss compared to baseline for all treatment groups receiving 0.01 mg/kg/24 h via SC infusion (NCT02431442) (85, 86)

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Optimized Fat Metabolism: Tesamorelin, in particular, has been shown to support reductions in visceral fat, while the synergistic effects of the triple stack may promote an overall increase in metabolic efficiency