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The STEP clinical trials showed semaglutide produced average weight losses of 15 percent or more in obese patients, rivaling results from weight loss surgery without the surgical risks

3, 4 Therefore, new patients with type 2 diabetes who meet the Special Authority criteria for funded treatment with a GLP-1 receptor agonist can be initiated on either liraglutide (Victoza * ) or dulaglutide (Trulicity)

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While this is beneficial for managing diabetes, it can sometimes excessively delay gastric emptying, leading to gastroparesis in some patients

Users experiencing multiple side effects simultaneously, such as dry mouth combined with severe constipation , fatigue , and headaches , should discuss overall tolerability with their prescriber