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Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

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The FDA has flagged emideltide/DSIP in a compounding safety-risk context because of insufficient safety information and concerns involving peptide impurities and immunogenicity, while existing human studies are too small and short-term to reliably assess long-term adverse effects

This reveals a critical principle: for predicting the clinical outcome of protein-binding drug interactions, understanding the drug's extraction ratio is more important than simply knowing its degree of protein binding