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A total of eight members of the GPX family are currently found, namely GPX1-GPX8

This condition not only affects cosmetic appearance but can also impair medication absorption, potentially reducing therapeutic efficacy

When the cells are exposed to oxidative stress, NRF-2 escapes the negative regulation of KEAP1 through the increase of NRF-2, the transcription of interleukins decreases the levels of antioxidant response elements increase

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Notably, these neuroprotective effects occurred independently of glycemic control, underscoring curcumins direct ability to counteract hyperglycemia-induced oxidative neuronal damage [212]