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The disadvantage is cost, complexity, and the current lack of retatrutide-specific patch formulations

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The GLP-1 receptor agonists used clinically are based on exendin-4 and native GLP-1 and are available as formulations for daily or weekly s.c

It is important to note that discontinuing tirzepatide is rarely necessary for joint symptoms alone unless a clear temporal relationship and lack of alternative explanation strongly suggest medication-related causation

Improved blood pressure control in this population could contribute meaningfully to symptom relief and better long-term outcomes.25 Improvement in glycemic control was evident among diabetic subgroups treated with GLP-1RAs, aligning with their established role in lowering blood glucose.26 However, the high heterogeneity observed among the studies indicates that the magnitude of this effect may be compromised by variability in the baseline characteristics such as HbA1c levels, duration of diabetes, different GLP-1RAs and their doses used