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Age-related changes in organ structure and function observed in older adults resemble those seen in patients with pathological GH deficiency

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This systems-level perspective is driving renewed provider interest in glutathione clinical applications across functional medicine and integrative care models

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This microenvironment-driven conversion is supported by the transcriptional upregulation of key stemness regulators such as OCT4, NANOG, and SOX2 and is further reinforced by epigenetic modifications such as promoter methylation or histone acetylation, which stabilize the reprogrammed state