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doi: 10.4103/0974-7753.114714 80 CostaMISarmento-RibeiroABGonalvesAC

A Phase 2 Dose Ranging, Randomized, Double Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis (PBC) With or Without an Inadequate Response to Ursodeoxycholic Acid (UDCA) (2021)

They found that this enzyme could survive temperatures up to 60 C (16)

Hyperglycemia impairs neutrophil-mediated bacterial clearance in mice infected with the lyme disease pathogen

It is expected that proteins interacting with the compound of interest will be stabilized or destabilized, leading to a change in the temperature at which the target protein denatures and precipitates out of solution