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90810.91371/journal.pone.0090891 (2014)

The nanosystem can release DOX by the low pH endosomes while up-taken by MDR/breast cancer cells and could silence the MDR1 gene and erythroblastosis virus E26 oncogene homolog 1 gene by MBs hybridizing with target sequences, plus it is capable of hindering DOX efflux transporter of P-glycoprotein expression and causing the progression of MDR breast cancer to desist

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These concerns led the researchers to conduct a series of preclinical studies to examine the carcinogenic potential that [Nle 4 , D-Phe 7 ]-MSH had in both in vivo and in vitro skin models