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For example, methylglyoxal, an enzymatic, and non-enzymatic product deriving from the glycolytic pathway (Martins et al., 2001

(6) The two hydroxyl groups in lutein make it more polar and hydrophilic (attracted to water) than other carotenoids, which means it is better suited to react with oxygen and act as an antioxidant by effectively scavenging reactive oxygen species

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Insomnia and sleep disruption deserve mention