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Vitamin C can be a beneficial adjunct in iron chelation therapy because it facilitates iron chelation and iron complex excretion

After 16 weeks, the berberine-treated group had greater reductions in body weight, BMI, waist circumference, liver fat content, and cholesterol and triglyceride levels, and greater improvement in glucose tolerance

Furthermore, the magnitude of the pooled effect progressively decreased from the Early Era to the Modern Era, suggesting that advances in obesity pharmacotherapy have narrowed, but not eliminated, the weight-loss advantage historically associated with surgery

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