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In tissue-repair research, angiogenesis matters because new blood vessels are what deliver oxygen and nutrients to the area being repaired

Alternative targets in TED include IL-17a (blocked by the IgG1s secukinumab (Cosentyx) and vunakizumab (NCT04737330, NCT05394857)), the IL-11 receptor (NCT05331300), the IL-6 receptor (NCT05331300), and vascular endothelial growth factor (NCT04311606)

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The 2025 meta-analysis by Alfalasi and colleagues, published via PMC, synthesized data from 16 studies and 6,098 total participants

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