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These discrepancies might be attributed to the timing of GLP-1RA intervention in the disease course

Its proposed mechanism of action includes stimulation of glucose-dependent insulin secretion, suppression of glucagon (via GLP-1), enhanced lipid metabolism (via GIP), and increased energy expenditure (via glucagon receptor activation)

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3.3.6 Natural compounds and TCM intervention in intervening ferroptosis in DN Numerous studies have reported that active components of traditional Chinese medicine (TCM) (121, 123, 125, 147, 169179) and TCM compound formulas (83, 120, 180186) can ameliorate renal injury and ferroptosis in DN by activating antioxidant proteins