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The researchers studied 6,370 adults in eight randomised controlled trials and three observational studies

Pharmacol Rev 54:101127 Talebi S, Bolhassani A, Azad TM, Arashkia A, Modaresi MH (2017) Immuno-stimulating peptide derived from HMGB1 is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines

Alternatively, it can be inhibited by non-specific agents: diamide (a thiol-oxidizing agent), N-ethylmaleimide (a thiol-alkylating compound) and butylhydroperoxide [25]

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