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Allen, D

Thalidomide is associated with edema, sinus bradycardia, venous thromboembolism, and lenalidomide is associated with hypersensitivity myocarditis, and high-dose interleukin-2 is associated with fulminant myocarditis

Some are commercially available and are standardized as to effectiveness

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As natural levels of this coenzyme decline with age or stress, some systems in the body can start to function less efficiently