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One group received only the medications, another received the medications plus ALC, and the third group received placebo

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Heart rate increases were also noted at higher doses of retatrutide, another effect potentially linked to glucagon-mediated increases in metabolic rate

Patients were randomly assigned to orforglipron (12 mg or 36 mg) or semaglutide (7 mg or 14 mg) with a treatment period of 52 weeks, from 22 September 2022 to 22 August 2025, and drugs were administered orally once per day