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Drug tolerance typically develops when an addictive substance has been misused, in rapid metabolizers where the body eliminates a medication at the shorter end of its half-life, or when someone has been taking a high dose of the same medication for a long period of time

10.1016/j.biotechadv.2021.107759 4 AliA.AlHussainiK

Excluded individuals had received any SARS-CoV-2 vaccine or did not have virology confirmation through the laboratory of SENAI CIMATEC

Even 1 kg of extra lean mass can lower mortality risk by ~1% in middle-aged and older adults

This study was conducted at a single center and included only weekly GLP-1 formulations, which may limit generalizability to other regimens such as daily agents or higher doses