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Complementary defense systems include the FSP1-coenzyme Q (CoQ) axis and the GTP cyclohydrolase 1-tetrahydrobiopterin (GCH1-BH4) pathway, both of which suppress lipid peroxidation independently of GPX4 (30)(31)(32)

2.1.3 Collapse of antioxidant defense mechanisms The antioxidant defense System in cells is critically dependent on glutathione peroxidase 4 (GPX4), a crucial metabolic enzyme that uses glutathione (GSH) to convert lipid peroxides into non-toxic alcohols, thereby minimizing harmful lipid peroxidation and safeguarding cells from ferroptosis

Int J Mol Sci 22:2954 Craveiro NS, Lopes BS, Toms L, Almeida SF (2020) Drug withdrawal due to safety: a review of the data supporting withdrawal decision

10.1155/2017/3715037 35 Strutyns'kaN

The GstA1 gene, which encodes a 29 kD GST protein (GST29) was specifically inducible by fungal infections and exogenous GSH, but not by various xenobiotics that typically induce GST activity (paraquat, atrazine, alachlor, metolachlor) (Mauch and Dudler, 1993)