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The peptide is unique among neuropeptides in several respects: it does not conform to typical neuropeptide structural motifs, its distribution in the brain and periphery differs from classical sleep-promoting substances, and it appears to exert effects through multiple pathways rather than through a single characterized receptor system

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Importantly, the observed inhibition of AMPK phosphorylation by EtOH in WT mice was absent from KO mice (Fig