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In mammals, nucleotide signaling activates the P2 receptorsP2X and P2Y and is countered by adenosine signaling ensuring homeostasis 15

Combining erastin with vitamin C has been shown to increase intracellular ferrous iron levels via the AMPK/Nrf2/HMOX1 axis, resensitizing PDAC cells to ferroptosis and presenting a novel therapeutic approach [151]

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In addition, lycopene reduced vascular superoxide anion and lipid peroxidation and modified antioxidant enzyme activity impaired by angiotensin-II [97]

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