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WT, Wilde-type C57BL6/J (WT) and Wild-type DBA/2

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A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

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232 These observations provide evidence for diabetes-related histone modification and related impaired insulin release