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Step-by-Step Skincare Guide to Achieving Acne-Free Skin 2

Endocrinology 113(1):270276

This gradual shift allows the body to adjust and avoid gastrointestinal side effects

Metabolic Concerns TMAO (Trimethylamine N-Oxide) Production: Recent concern (2025): Approximately 90% of oral ALC metabolized to TMAO by gut microbiota[21] Plasma TMAO levels: Can reach 50 M after supplementation (1.5 g dose)[21] Cardiovascular risk: Elevated TMAO previously associated with adverse cardiovascular outcomes in observational studies Clinical significance: Uncertain

Linked to obesity and diabetes, NAFLD and NASH are increasingly recognized as manifestations of metabolic syndrome, a cluster of conditions linked to increased cardiovascular risk