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La -butirobetana se hidroxila en la posicin 3 para dar como producto final la carnitina, reaccin catalizada por la enzima butirobetana dioxigenasa (BB-DO, EC 1.14.11.1), que requiere hierro (II), 3-oxoglutarato y cido ascrbico como cofactores

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[21] After the solution is deposited into muscle, cholecalciferol diffuses into the circulation bound to vitamin-D-binding protein and undergoes 25-hydroxylation in hepatocytes, yielding 25-hydroxyvitamin D, the principal circulating biomarker of status

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