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Receptor-selective peptides are studied for their ability to support controlled investigations into receptor-binding behavior, signaling mechanisms, and peptide pathway interactions within laboratory environments

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Recently, we demonstrated that the cyclolignan PPP inhibited phosphorylation of IGF-1R without interfering with insulin receptor activity (Girnita et al, 2004), as well as it reduced phosphorylated Akt, caused apoptosis and induced tumour regression in xenografted mice