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But GLP-1 is also produced in the central nervous system, predominantly in the brainstem, and its receptors are expressed in multiple regions of the brain, including the striatum and nucleus accumbens

However, multiple forces are converging to limit their future: 1

d , Venn diagram showing the overlap between the SynGO database and the 506 uniquely differentially expressed proteins in response to GLP-1MK-801

[16] Reported rates from trials include: Nausea: ~44% Vomiting: ~25% Diarrhea: ~31% Constipation: ~23% Dyspepsia: ~10% These effects reflect slowed gastric motility and are usually mild, but can lead to clinical implications: Dehydration Electrolyte abnormalities ED presentations for poor oral intake

This VAS paper is today a classic methods paper in this field [3] and has been cited 2,382 times