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Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. Free radical biology & medicine vol

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It highlights the distinction between adaptive circadian remodeling during normal aging and pathological circadian disruption linked to disease, providing a conceptual framework for understanding age-dependent alterations in sleepwake regulation