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Since penetratin has the disadvantages that relatively high doses of penetratin are required for nasal insulin absorption (Khafagy et al., 2009a), several analogs of penetratin were designed looking to optimize the efficacy of transepithelial insulin delivery

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Since research on these drugs is still relatively young, it will take some time before we have more complete information about their long-term safety and benefits

Evaluation of muscle biopsies can provide an accurate diagnosis in a large percentage of these cases, allow the muscle pathologist to make an accurate prognosis, and suggest specific therapies