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Bariatric surgery remains highly effective in the treatment of severe obesity, and on average leads to more weight loss than GLP-1 medications

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Conclusively, therapy with exenatide and rosiglitazone, in addition to metformin, offset the weight gain observed with rosiglitazone and elicited an additive effect on glycemic control with significant improvements in -cell function and insulin sensitivity

35 In people with type 2 diabetes and established cardiovascular disease, two years of low-dose semaglutide (0.5 or 1 mg) reduced the risk of a composite outcome of cardiovascular death, nonfatal myocardial infarction or nonfatal stroke by 26%, primarily driven by stroke reduction