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Future research should prioritize long-term safety studies, real-world effectiveness analyses, and investigations into predictors of treatment response

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The involvement and underlying mechanism of LCN2 in METH-PH formation were explored using a METH-PH mouse model and a coculture system of macrophages and pulmonary artery smooth muscle cells

Fine regulation of mitochondrial activity and redox status is particularly important, since oocytes are highly dependent on oxidative phosphorylation for ATP generation, given the lack of expression of the high-affinity insulin-regulated glucose transporter SLC2A4 (or GLUT4) and low activity of the rate-limiting glycolysis enzyme phosphofructokinase [16,17]