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However, these mutations in the D3 protease background, genotype D3(415)2, resulted in 7.7-fold circuit activation, whereas the same two mutations in the WT background, E(415)1, resulted in only 2.6-fold activation

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found that VPA at a dosage of 300 mg/kg once a day for 4 weeks, changed the way the left ventricle worked, made the sympathetic nervous system less active, and slowed down the heart's remodeling (Liu et al., 2017)

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