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Description

Opioid-induced hyperalgesia is a paradoxical increase in pain sensitivity caused by repeated opioid exposure

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This randomized, controlled trial compared the effects of L-citrulline (6g) , combined L-citrulline (2g) + glutathione (200mg) , and placebo over 4 weeks

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10.1001/jamanetworkopen.2024.6221 74

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