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Studies in rodents and primates have signaled that GLP-1 agonists may drive a reduction in intake of alcohol and drugs of abuse, and clinical trials have been initiated to investigate whether preclinical findings can be translated to humans

The efficacy of systemic GLP-1R agonists to attenuate cocaine seeking is associated with decreased activity of dopamine cells in the VTA VTA dopamine neurons mediate the rewarding effects of cocaine and increased dopamine cell firing in the VTA is necessary for cocaine seeking 58,59

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Thus, TNBS promotes two independent mechanisms of injury, GSH depletion and ROS generation, both being required for the manifestation of mucosal injury as GSH limitation renders intestine susceptible to the TNBS-induced ROS overgeneration

Control of gluconeogenesis by metformin: Does redox trump energy charge