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In contrast, the C2 domain is composed primarily of acidic amino acids, resulting in an overall negatively charged surface [226]

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[1] [4] While the relevance to humans remains uncertain, Rybelsus is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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This aligns with preventive wellness rather than clinical disease management