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PD-1 and its ligand PD-L1 constitute a pair of negative immunosuppressive molecules that perform critical functions in maintaining the equilibrium between T-cell activation, immune tolerance, and progression of pathological conditions [51, 79]

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Experimental findings suggest that it may influence collagen synthesis, antioxidant activity, and gene expression patterns involved in tissue repair and regeneration

Therefore, it might be that metabolism-regulating miRNAs play a vital role in the dynamics of metabolic homeostasis