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Thus, with pathologic HNE concentrations (10M and higher) for rat GCLC, ERK activation was required for the HNE-mediated induction but for human GCLC, JNK activation was essential and Nrf2 was not required (Iles and Liu, 2005)
2019;140:e596e646
glutathione peroxidase-related protein 2
For instance, trimethylamine N-oxide (TMAO), a metabolite derived from gut microbial activity, has demonstrated the ability to stimulate immune activation and enhance the efficacy of immune checkpoint blockade (ICB) in mouse models of pancreatic cancer
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