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(106) included seven randomized, placebo-controlled trials that exclusively enrolled individuals with high blood pressure, i.e., with systolic blood pressure (SBP) 140 mm Hg and/or diastolic blood pressure (DBP) 90 mm Hg

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Advanced protocol: Some researchers use up to 2.5 to 3 mg weekly, though evidence supporting additional benefit from higher doses remains limited while side effect potential increases

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