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This study evaluated the therapeutic potential of non-gene-edited human chemically induced pluripotent stem cell-derived neural stem cells (hCiPSC-NSCs) in a prenatal valproic acid (VPA)-induced rat model of ASD, using a dual-pathway administration strategy (intravenous systemic delivery combined with an intracerebroventricular boost)

Abbreviations AASD: The Arabic Association for the Study of Diabetes and Metabolism ACEI: Angiotensin converting enzyme inhibitors ACTH: Adrenocorticotrophic hormone AGB: Adjustable gastric banding AIH: Autoimmune hypoglycemia BS: Bariatric surgery BG: Blood glucose CGM: Continuous glucose monitoring CIRCI: Critical illness-associated adrenocortical insufficiency CKD: Chronic kidney disease CT: Computed tomography DDP-4: Dipeptidyl peptidase-4 EDS: Early dumping syndrome ESLD: End-stage liver disease ESRD: End-stage renal disease FH: Fasting hypoglycemia GABA: Gamma-aminobutyric acid GH: Growth hormone GIP: Gastrointestinal peptide GLP: Glucagon-like peptide GV: Glucose variability HCC: Hepatocellular carcinoma HD: Hemodialysis HOMA-IR: Homeostatic Model Assessment for Insulin Resistance IAS: Insulin autoimmune syndrome ICU: Intensive care unit IGF: Insulin-like growth factor LDS: Late dumping syndrome MAOIs: Mono-Amin Oxidase Inhibitors MEN: Multiple endocrine neoplasia MMTT: Mixed meal tolerance test MRI: Magnetic resonance imaging NICTH: Non-islet cell tumor hypoglycemia NSAIDs: Nonsteroidal anti-inflammatory drugs OGTT: Oral glucose tolerance test OTC: Over the counter PBH: Post-bariatric-surgery hypoglycemia PPH: Postprandial hypoglycemia POC: Point-of-care RH: Reactive hypoglycemia rhGH: Recombinant human growth hormone RRT: Renal replacement therapy RYGB: Roux-en-Y gastric bypass SAH: Sepsis associated hypoglycemia SG: Sleeve gastrectomy SGLT 2: Sodium glucose transporter 2 SSA: Somatostatin analogues SSRIs: Selective serotonin re-uptake inhibitors SOFA: Sequential organ failure assessment SU: Sulfonylurea T2DM: Type 2 diabetes mellitus TCAs: Tricyclic antidepressants TIA: Transient ischemic attack References Ng CL

After a median follow-up of 8.5 months, the cohort generated 36 serious renal events

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Foroud, A