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10.1111/j.1365-2826.2008.01686.x 31 CareyA

Both GIP and GLP-1 exert direct or indirect effects on adipose and hepatic tissues to regulate lipid and glucose metabolism

The most commonly reported adverse effects in these trials were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the broader class of GLP-1 receptor agonists

Leveraging strong penetrating ability to traverse multiple physiological barriers

NICE guidance (NG145) recommends checking TSH levels approximately 68 weeks after any significant weight change or dose adjustment of levothyroxine, then annually once stable