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Here, we found that linagliptin significantly improved glucose tolerance at doses of 3 mg/kg and 30 mg/kg in VilCre control, Gcg RA VilCre and Gcg RA Null mice at 15, 30, 45 and 60 min after an oral glucose gavage (Fig

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In doing so, we advocate for a paradigm that moves beyond traditional indications, embracing the full spectrum of GLP-1R agonists in areas such as primary prevention, microvascular protection, and metabolic liver disease, and metabolic disorders that include cardio-kidney-metabolic (CKM) syndromea systemic disorder characterized by interrelated metabolic, renal, and cardiovascular dysfunction and a broader cardio-renal-metabolic axis that includes central obesity, insulin resistance, dyslipidemia, hypertension, and pre-diabetic states

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