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Indeed, increased GLUT1 expression localized to intestinal epithelial membranes facilitates luminal glucose excretion, potentially reducing intracellular glucose accumulation and mitigating the Warburg effect, a hallmark of tumor metabolism
These digestive effects happen because GLP-1 medications work throughout your entire digestive system, slowing how quickly food moves through your stomach and intestines
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Thus, the cellular ratio of NADPH to NADP + has cascade effects on the ability of the glutathione pathway to act as a defense against oxidative stress in a cell