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While the direct recognition of PGN by TLR2 remains a subject of academic debate, its synergistic interplay with other TLR-mediated pathways is critical for orchestrating the robust inflammatory response characteristic of bovine systemic dysbiosis

Clinical research should further validate the potential application of HIF-2 in personalized treatment, alongside ferroptosis markers like GPX4, to precisely regulate the survival environment of chondrocytes, advancing and refining OA treatment

Vaughn AE, Deshmukh M

No additional ethical approval is needed