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The inhibition of protein kinase C (PKC), NADPH oxidase, and NF-B signaling exhibited anti-oxidative and anti-inflammatory effects in endothelial cells, accompanied by the upregulation of protective anti-oxidative enzymes [57]

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Research published in 2025 demonstrates that when all four elements are in place, researchers can lose 13% of body weight while sacrificing only 3% of muscle mass

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