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In 2025, the American Association of Clinical Endocrinology updated its Obesity Algorithm, which highlights the importance of preserving skeletal muscle during medical weight-loss interventions: patients who retain strength tend to experience fewer side effects, more energy, and better long-term weight maintenance

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Studies show 50% of lost weight typically returns within six months after discontinuation if lifestyle changes weren't sustained

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Semaglutide is roughly 18 times larger