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Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFkappaB signaling

Safety was also strong: in multiple ascending dose (MAD) trials, GI side effects were mild, dose-dependent, and occurred mainly in the first week

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As the parameters measured did not differ significantly between the two LC doses used, the study concluded that a low dose of LC was sufficient to render positive effects on pregnancy and offspring outcomes in pregnant mice [42]

Journal of Physiology, Paris , 87 (5), 313327