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Semaglutide GLP-1, acting as a glucagon-like peptide-1 (GLP-1) receptor agonist, exerts its effects by impacting appetite regulation in the brain, leading to reduced food consumption, and calorie intake, and ultimately facilitating weight reduction

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(2) epigenetic modification, such as methyl donor S-adenosyl methionine (SAM) from the methionine cycle

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Still, a large-scale French study did find a potential link between GLP-1 use and thyroid cancer, especially in patients who used the drug for more than a year