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The oral route of administration pose challenges due to the drugs high molecular weight, extremely low absorption with the commercially available oral tablets and the drugs sensitivity to the heat required to compound it into a lozenge

Notably, 50.7% of participants receiving CagriSema reached the BMI threshold for non-obesity by the end of the trial, compared with 10.2% of the placebo group

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Track record and long-term data: Semaglutide has longer real-world use for obesity treatment

Chelation, that is multiple coordination bonds between organic molecules and metals, is very common in the body and at the heart of enzymes with a metal cofactor such as copper or zinc