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Realistic expectations matter when your baseline diet is adequate

No plausible mechanism for additive effects

Studies using constant light to decrease melatonin production show it causes Alzheimer s-like damage in the cells along with increasing the need for antioxidants such as SOD and monoamine oxidase.[ref] There have been quite a few recent studies and reviews pointing to the role of both low melatonin and circadian disruption in the accumulation of amyloid-beta plaque.[ref] So what are the results of human studies that have used long-term melatonin supplementation to prevent Alzheimers disease

In the meantime, results from earlier trials provide insight into the key benefits observed so far: Appetite suppression and weight reduction: A 26-week phase 2 study, involving 706 overweight and obese participants without T2D, showed a weight reduction of -9.7% (-22.7 lb) with 2.4 mg/week and -10.8% (-25.4 lb) with 4.5 mg/week of cagrilintide

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